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(Albany, US) On October 22, 2026, DelveInsight’s “Cholangiocarcinoma Pipeline Insight 2026” report provides comprehensive insights into 55+ companies and 60+ pipeline drugs in the cholangiocarcinoma pipeline landscape. It covers the Cholangiocarcinoma Pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Cholangiocarcinoma pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Stay ahead in understanding the Cholangiocarcinoma Treatment Landscape @ https://www.delveinsight.com/sample-request/cholangiocarcinoma-cca-pipeline-insight

Key Takeaways from the Cholangiocarcinoma Pipeline Report

• On October 21, 2026- Summit Therapeutics entered into a clinical trial collaboration with ECOG-ACRIN Cancer Research Group to evaluate ivonescimab in combination with chemotherapy for the first-line treatment of advanced biliary tract cancer, including cholangiocarcinoma.
• On October 12, 2026- Focused Ultrasound Foundation announced the launch of the CODAH clinical trial to evaluate histotripsy in combination with durvalumab for the treatment of intrahepatic cholangiocarcinoma.
• On October 12, 2026, Leads Biolabs announced that the U.S. FDA had granted Fast Track designation to opamtistomig (LBL-024) for the first-line treatment of advanced or metastatic biliary tract cancer.
• On October 1, 2026, Memorial Sloan Kettering Cancer Center reported on the FDA approval of lirafugratinib (Lyrfigtu), developed by Elevar Therapeutics, for previously treated cholangiocarcinoma with FGFR2 fusions or other rearrangements. The FDA approval was granted on September 23, 2026.
• DelveInsight’s Cholangiocarcinoma pipeline report depicts a robust space with 55+ active players working to develop 60+ pipeline therapies for Cholangiocarcinoma treatment.
• The leading Cholangiocarcinoma Companies such as Merck Sharp & Dohme, Eisai, RedHill Biopharma Limited, TransThera Science, Kinnate Biopharma, Taiho Oncology, Bristol-Myers Squibb, AstraZeneca, Jiangsu Hengrui Medicine Co. Ltd., GlaxoSmithKline, Beijing InnoCare Pharma, Genoscience, 3D Medicines, Innovent Biologics (Suzhou) Co. Ltd., QED Therapeutics, Hutchison MediPharma, TriSalus Life Sciences, Relay Therapeutics, Eli Lilly and Company, Medivir, Boehringer Ingelheim, Compass Therapeutics, Intensity Therapeutics, Sirnaomics, Wellmarker Bio and others.
• Promising Cholangiocarcinoma Pipeline Therapies such as PEMAZYRE (pemigatinib), TIBSOVO (ivosidenib), LYTGOBI (futibatinib), Imfinzi (durvalumab), Melphalan, Derazantinib, Futibatinib (TAS-120), E7090, TT-0040, and others.

Gain in-depth knowledge of key clinical trials, emerging drugs, and market opportunities @ Cholangiocarcinoma Clinical Trials Assessment

Cholangiocarcinoma Overview

Cholangiocarcinoma is an epithelial cell malignancy arising from varying locations within the biliary tree and showing markers of cholangiocyte differentiation. The most contemporary classification based on anatomical location includes intrahepatic, perihilar, and distal cholangiocarcinoma. Many cases of cholangiocarcinoma arise de novo and do not have a specific risk factor, but there are a number of risk factors that have been identified, including primary hepatobiliary disease, genetic disorders, toxic exposures, and infections. Similar to many malignancies, cholangiocarcinoma arises from precursor lesions such as the more common biliary intraepithelial neoplasia and the less common intraductal papillary mucinous neoplasm. Normal epithelium becomes one of these premalignant lesions through mutations in a variety of oncogenes and tumor suppressor genes. While the specific molecular pathway has not been identified, cholangiocarcinomas harbor mutations in genes such as RAS, BRAF, p52, SMAD4, and more.

Cholangiocarcinoma Emerging Drugs Profile

• Pembrolizumab: Merck Sharp & dohme

Pembrolizumab is a highly selective humanized monoclonal IgG4 antibody directed against the PD-1 receptor on the cell surface. The drug blocks the PD-1 receptor, preventing binding and activation of PD-L1 and PD-L2. This mechanism causes the activation of T-cell mediated immune responses against tumor cells. It is currently being evaluated in Phase III stage of development to treat biliary tract cancer.

• E7090: Eisai

Discovered in-house by Eisai’s Tsukuba Research Laboratories, E7090 is an orally available novel tyrosine kinase inhibitor that demonstrates selective inhibitory activity against fibroblast growth factor receptors (FGFR) FGFR1, FGFR2, and FGFR3. Distinct from prior known FGFR inhibitors, E7090 has a basic structure that lacks the dimethoxyphenyl moiety, and in a kinetic interaction analysis study, it was observed that E7090 demonstrates antitumor effects due to inhibition of kinase activity with a binding mode (Type V) that exhibits rapid and potent binding as well as high selectivity to FGFR1. A Phase II clinical trial of E7090 is underway to evaluate the efficacy and safety in patients with cholangiocarcinoma with FGFR2 gene fusion. E7090 received orphan drug designation for a prospective indication for unresectable biliary tract cancer with FGFR2 gene fusion by the Ministry of Health, Labour and Welfare, Japan.

• ABC294640: RedHill Biopharma Limited

ABC294640 (Opaganib) is a first-in-class, proprietary sphingosine kinase-2 (SK2) selective inhibitor, administered orally, with anticancer, anti-inflammatory, and antiviral activities. Opaganib inhibits SK2, a lipid kinase that catalyzes the formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNFα signaling, and other inflammatory cytokine production. Specifically, by inhibiting the SK2 enzyme, opaganib blocks the synthesis of S1P, which regulates fundamental biological processes such as cell proliferation, migration, immune cell trafficking and angiogenesis, and is also involved in immune modulation and suppression of innate immune responses from T cells. Preliminary evidence suggests that because of its specificity for targeting SK2 rather than SK1, opaganib may have a better therapeutic ratio than nonspecific sphingosine kinase inhibitors or those targeting only SK1. Currently, the drug is being evaluated in the Phase II stage of its development for the treatment of cholangiocarcinoma.

• TT-00420: TransThera Science

TT-00420 is a highly innovative, clinical-stage, spectrum-selective kinase inhibitor that exerts antitumor effects by targeting tumor cells and improving the tumor microenvironment. A large number of preclinical studies have found that TT-00420 has a promising inhibitory effect on triple-negative breast cancer, cholangiocarcinoma, and other malignant tumors. TT-00420 was granted Orphan Drug Designation and fast track designation by the FDA and is currently in the Phase II stage of its development for the treatment of cholangiocarcinoma.

• KIN-3248: Kinnate Biopharma

KIN-3248 is a small molecule kinase inhibitor that targets cancer associated alterations in the FGFR2 and FGFR3 genes. KIN-3248 aims to address the primary driver alteration and clinically observed and predicted FGFR2/3 mutations. The company is currently evaluating the safety and tolerability of KIN-3248 in the Phase I stage of its development for the treatment of cholangiocarcinoma.

The Cholangiocarcinoma Pipeline Report Provides Insights into

• The report provides detailed insights about companies that are developing therapies for the treatment of Cholangiocarcinoma with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Cholangiocarcinoma Treatment.
• Cholangiocarcinoma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Cholangiocarcinoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Cholangiocarcinoma market

Uncover critical updates on therapeutic innovations and their potential impact on patients and the healthcare industry @ Cholangiocarcinoma Unmet Needs

Cholangiocarcinoma Companies

Merck Sharp & Dohme, Eisai, RedHill Biopharma Limited, TransThera Science, Kinnate Biopharma, Taiho Oncology, Bristol-Myers Squibb, AstraZeneca, Jiangsu Hengrui Medicine Co. Ltd., GlaxoSmithKline, Beijing InnoCare Pharma, Genoscience, 3D Medicines, Innovent Biologics (Suzhou) Co. Ltd., QED Therapeutics, Hutchison MediPharma, TriSalus Life Sciences, Relay Therapeutics, Eli Lilly and Company, Medivir, Boehringer Ingelheim, Compass Therapeutics, Intensity Therapeutics, Sirnaomics, Wellmarker Bio and others.

Cholangiocarcinoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical

Cholangiocarcinoma Products have been categorized under various Molecule types such as

• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy

See the latest progress in drug development and clinical research @ Cholangiocarcinoma Market Drivers and Barriers, and Future Perspectives

Scope of the Cholangiocarcinoma Pipeline Report

• Coverage- Global
• Cholangiocarcinoma Companies- Merck Sharp & Dohme, Eisai, RedHill Biopharma Limited, TransThera Science, Kinnate Biopharma, Taiho Oncology, Bristol-Myers Squibb, AstraZeneca, Jiangsu Hengrui Medicine Co. Ltd., GlaxoSmithKline, Beijing InnoCare Pharma, Genoscience, 3D Medicines, Innovent Biologics (Suzhou) Co. Ltd., QED Therapeutics, Hutchison MediPharma, TriSalus Life Sciences, Relay Therapeutics, Eli Lilly and Company, Medivir, Boehringer Ingelheim, Compass Therapeutics, Intensity Therapeutics, Sirnaomics, Wellmarker Bio and others.
• Cholangiocarcinoma Pipeline Therapies- PEMAZYRE (pemigatinib), TIBSOVO (ivosidenib), LYTGOBI (futibatinib), Imfinzi (durvalumab), Melphalan, Derazantinib, Futibatinib (TAS-120), E7090, TT-0040, and others.
• Cholangiocarcinoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Cholangiocarcinoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

Access the Full Cholangiocarcinoma Pipeline Analysis Today! @ Cholangiocarcinoma Drugs and Companies

Table of Contents

1. Introduction
2. Executive Summary
3. Cholangiocarcinoma: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Cholangiocarcinoma– DelveInsight’s Analytical Perspective
7. Late Stage Products (Phase III)
8. Pembrolizumab: Merck Sharp & dohme
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. E7090: Eisai
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. KIN-3248: Kinnate Biopharma
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name: Company name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Cholangiocarcinoma Key Companies
21. Cholangiocarcinoma Key Products
22. Cholangiocarcinoma Unmet Needs
23. Cholangiocarcinoma Market Drivers and Barriers
24. Cholangiocarcinoma Future Perspectives and Conclusion
25. Cholangiocarcinoma Analyst Views
26. Cholangiocarcinoma Key Companies
27. Appendix

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